Preparation of novel streptokinase mutants as improved thromboly

Details Preparation of novel streptokinase mutants as improved thromboly Preparation of novel streptokinase mutants as improved thromboly

1995-12-06

1999-03-02

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 435 711, 435 712, 4351723, 4352523, 43525233, 4353201, 536 232, C12N 970, C12N 1500, C12N 120, C12P 2106

Patent

active

058769994

ABSTRACT:
Mutants of streptokinase in which one or more amino acid residues in the region of Pro58-Lys59-Ser60-Lys61 were replaced by other amino acids become better fibrinolytic agents. The mutants are resistant to the hydrolytic inactivation by plasmin and are more efficient in inducing fibrinolysis of plasma clots.

REFERENCES:
Shi et al. (1994) Biochem. J. 304, 235-241.

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