Preparation of noroxymorphone from morphine

Details Preparation of noroxymorphone from morphine Preparation of noroxymorphone from morphine

1998-07-16

1999-12-28

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 44, 546 45, 546 46, 546 74, C07D48902, C07D22128

Patent

active

060083549

ABSTRACT:
The invention provides processes for the conversion of normorphinone and its derivatives, which can be synthesized from morphine, to the corresponding 14-hydroxynormorphinone and its derivatives including oxycodone, oxymorphone, noroxymorphone and naltrexone. Noroxymorphone is a key intermediate for the production of important narcotic analgesics and antagonists. The invention also provides certain novel intermediates.

REFERENCES:
patent: 3819636 (1974-06-01), Wiesner
patent: 4668685 (1987-05-01), Shammi
patent: 4912114 (1990-03-01), Reves
Schimidhammer et al, Chemical Abstract vol. 123 No. 12477 "Sxn and Bio Eval of 14-Alkoxy Morphianan " (1995).

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