Preparation of nitroesters for coronary artery therapy

Details Preparation of nitroesters for coronary artery therapy Preparation of nitroesters for coronary artery therapy

1984-09-14

1986-09-09

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514509, A61K 3134, A61K 3121

Patent

active

046110089

ABSTRACT:
A gel or gel preparation of improved stability and shelf life having an action on the coronary arteries comprising nitroesters, an oil base and finely disperse silica, wherein the finely disperse silica contains hydrophilic and hydrophobic, finely disperse silica is disclosed. A method for making the gel preparation is also disclosed.

REFERENCES:
patent: 3028307 (1962-04-01), Ninger
patent: 3251739 (1966-05-01), Petersen
patent: 4112115 (1978-09-01), Coghlan
patent: 4322433 (1982-03-01), Leslie et al.
Chem. Abst. 82:127175j (1975) Tamchyna et al.
Chem. Abst. 99:181480n (1983)-Nitto Electric Ind. Co.
Chem. Abst. 102:12410w (1985)-Enscore et al.
Remington's Pharmaceutical Sci. 1980-pp. 284 & 1264-Mack Publ. Co.

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