Preparation of nicotinamide

Details Preparation of nicotinamide Preparation of nicotinamide

1985-11-14

1987-07-21

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07B 4306, C07D21382

Patent

active

046819460

ABSTRACT:
A process for the preparation of nicotinamide by amidation of a nicotinic acid
icotinamide melt, vacuum distillation of the amidation mixture, removal of the nicotinamide as the bottom product and recycling of the top product, depleted with respect to nicotinamide, into the amidation stage together with addition of fresh amounts of nicotinic acid.

REFERENCES:
patent: 2412749 (1946-12-01), Pike et al.
patent: 2916494 (1959-12-01), O'Brochta
patent: 4327219 (1982-04-01), Gelbein
Pratt, H. R. C. "Countercurrent Separation Processes" pp. 191-209 (1967) Elsevier Publishing Co.
Karger, B. L. et al. "An Introduction to Separation Science" pp. 181-210 Wiley & Sons, New York (1973).
CRC Handbook of Chemistry and Physics, 62nd Ed. (1981) p. C.-398.
Hammond, "Separation and Purification of Materials" New York Philosophical Library (1958) pp. 19-22.

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