Preparation of native oncornavirus envelope subunits and vaccine

Details Preparation of native oncornavirus envelope subunits and vaccine Preparation of native oncornavirus envelope subunits and vaccine

1978-12-28

1983-09-27

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424177, A61K 3912, A61K 3702

Patent

active

044068859

ABSTRACT:
Non-denatured [gp90] is isolated from oncornavirus envelopes including feline and murine leukemia virus envelopes and utilized as vaccines. The materials as isolated may be used directly on in various compositions.

REFERENCES:
Salerno et al. J. Natl. Cancer Inst. 61(6): 1487-1493 Dec. 1978, (Received Mar. 3, 1978, accepted Jul. 23, 1978) Feline Leukemia Virus Envelope Glycoprotein Vaccine: Preparation and Evaluation of Immunizing Potency in Guinea Pig and Cat.
Strand et al. J. Biol. Chem. 251(2): 559-564, Jan. 25, 1976, Structural Protens of Ribonucleic Acid Tumor Viruses:Purification of Envelope, Gore and Internal Components.
De Noronha et al. Virology 85:617-624, (1978) Influence of Antisera to Oncornavirus Glycoprotein (GP71) onInfections of Cats with Feline Leukemia Virus.
Fischinger et al. Virology 71:169-184, (1978) Neutrausation of Homologous and Heterologous Oncornaviruses Against the P15E and GP71 Polcypeptides of Friend Murine Leukemia Virus.
Pinter et al. Virology 83(2):417-422, Dec. 77, The Presence of Disulfide-Linked GP70-P15E Compexes in AKR Murine Leukemia Virus.
Strand et al. Virology 13(1):171-180, Jan. 1974 Structural Proteins of Mammalian Oncogenic RNA Viruses: Multiple Antigenic Determinants of the Major Internal Protein and Envelope Glycoprotein.
Schafer et al. Virology 63:48-59, (1975), Polypeptides of Mammalian Oncornaviruses II. Characterization of a Murine Leukemia Virus Polypeptide (P15) Bearing Interspecies Reactivity.
Ihle et al. Virology 63:60-67, (1975) Polypeptides of Mammalian Oncornaviruses III. Localization of P15 and Reactivity with Natural Antibody.
Ikeda et al. J. Virol. 14(5):1274-1280, Nov. 1974, Biological Expression of Antigenic Determinants of Murine Leukemia Virus Proteins AP69/71 and p. 30.
Famulari et al. J. Virol. 20(2):501-508, Nov. 1976 Presence of Murine Leukemia Virus Envelope Proteins GP70 and p15(E) in a Common Polyprotein of Infected Cells.
Hunsmann et al. Virology 66:327-329, (1975) Properties of Mouse Leukemia Viruses, IX, Active and Passive Immunization of Mice Against Fried Leukemia with Isolated Viral GP.sub.71 Glycoprotein and its Corresponding Antiserum.
Schafer et al. Javma 158(6):1092-1098, Mar. 15, 1971, A Test System for Identification of the Antigen Shared by Leukemia Viruses of the Cat and other Mammalian Species.

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