Preparation of N-(phosphonoacetyl)-L-aspartic acid

Details Preparation of N-(phosphonoacetyl)-L-aspartic acid Preparation of N-(phosphonoacetyl)-L-aspartic acid

1978-08-10

1979-12-18

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560171, 260544Y, C07F 938

Patent

active

041794648

ABSTRACT:
Improved methods for preparation of the tetrasodium and disodium salts of N-(phosphonoacetyl)-L-aspartic acid (PALA) are disclosed. The present methods are well suited for preparation of these products in large amounts. Particular aspects of these methods include: (1) initial preparation of the PALA moiety as the dibenzyl ester; (2) the complete removal of impurities in the form of acetic acid and sodium acetate from disodium PALA by turbulent flow precipitation; and (3) preparation and purification of the cyclohexylammonium salt of dibenzyl PALA which ultimately results in a purer final product.

REFERENCES:
patent: 3417098 (1968-12-01), Anatol
patent: 4016148 (1977-04-01), Ratcliffe et al.
Vogel, "Practical Organic Chemistry" (1948), pp. 122-131.

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