Preparation of n-formamidoyl[(s)-1-t-butoxy-3-methyl-2-amino)]1,

Details Preparation of n-formamidoyl[(s)-1-t-butoxy-3-methyl-2-amino)]1, Preparation of n-formamidoyl[(s)-1-t-butoxy-3-methyl-2-amino)]1,

1986-07-03

1989-05-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 62, 549467, C07D491048, C07D491147, C07D30779

Patent

active

048352764

ABSTRACT:
The present invention is directed to an enantioselective synthesis of 1,3,4,6,7,12b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one which is an intermediate in the production of the .alpha..sub.2 -adrenergic antagonist (2R,12bS)-N-(1,3,4,6,7,12-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-yl) -N-methyl-2-hydroxy-ethanesulfonamide hydrochloride.

REFERENCES:
patent: 4690928 (1987-09-01), Huff et al.
patent: 4721787 (1988-01-01), Hutchinson
Loewe and Meyers, "An Asymmetric Synthesis of Indole Allcenloids", Tetrahedron Letters, vol. 26 No. 28 p. 3293 (1985).
Meyers, "Formamidines as Precursors to .alpha.-Amino Carbanions & Their Appl. to Asymm. C-C Bond-Forming Reactions", Aldrich. Act., vol. 18, No. 3 (1985).

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