Preparation of N-acylaminomethylphosphonic acid

Details Preparation of N-acylaminomethylphosphonic acid Preparation of N-acylaminomethylphosphonic acid

1992-10-15

1994-06-28

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

562 15, C07F 938

Patent

active

053248554

ABSTRACT:
N-acylaminomethylphosphonic acid is prepared from an N-methylolamide compound and a phosphorus trihalide. The starting compounds are mixed and heated in an aprotic solvent in the presence of water in a 0.25 to 2.5 times molar amount relative to the phosphorus trihalide at 60.degree. to 160.degree. C., and the reaction mixture is contacted with water. The N-methylolamide compound is a compound selected from the group consisting of N-methylol-lower alkylamides and N-methylolarylamides. The phosphorus trihalide is preferably phosphorus trichloride. As the aprotic solvent is used one or more of hydrocarbons, halogenated hydrocarbons, ethers, polyethers, nitriles, and aromatic nitro compounds. The mixing may be carried out at a temperature of 60.degree. C. The water present at the initiation of the reaction is in a 1.0 to 1.8 times molar amount relative to the phosphorus trihalide.

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Sb. Vys. Sk. Chem. Technol. Praze. Org. Chem. Technol., C28, p. 115.
J. Prakt Chem., vol. 329, No. 1, p. 19.
Synthesis 1989, No. 4, p. 547.

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