Preparation of N-acylamino acid esters and N-acylamino acetals

Details Preparation of N-acylamino acid esters and N-acylamino acetals Preparation of N-acylamino acid esters and N-acylamino acetals

2000-08-16

2004-05-25

Killos, Paul (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

Reexamination Certificate

active

06740774

ABSTRACT:

The invention relates to a process for preparing N-acylamino acid esters and N-acylamino acetals.
A large number of different methods for synthesizing amino acids and their esters are known. A review is given, inter alia, in Ullmanns Encyclopedia of Industrial Chemistry, Vol. A2, 57-97, VCH Weinheim 1985.
Industrial syntheses of D,L-&agr;-amino acids, for example the Strecker synthesis, use aldehydes as starting materials, which are reacted with NH
3
and HCN to give aminonitriles. The nitrile group can subsequently be reacted with alcohols or water to give the corresponding esters and amino acids, respectively.
DE-A-3145736 describes a process for preparing N-formyl-&agr;-amino acid esters by reacting aminonitriles—for example from the Strecker synthesis—with an appropriate alcohol and formamide in the presence of hydrogen chloride.
Also known is the preparation of N-formyl-D,L-alanine from pyruvic acid by boiling with ammonium formate in formic acid [F. Yoneda and K. Kuroda, J. Chem. Soc. Chem. Commun., 1982, 927-929].
N-Formylalanine esters are used, inter alia, for preparing vitamin B
6
(Pyridoxine) [Review by König and Böll, Chem. Ztg. 100 (1976), 107/8] and isocyanic acid, for example according to Ugi, Angew. Chem. 77 (1965), 492.
The processes described have the disadvantage that the starting materials used are finished amino acids or precursors thereof—for example cyanohydrins or aminonitriles from the Strecker synthesis—which have to be prepared beforehand in a separate process.
It is an object of the present invention to provide a process for preparing N-acylamino acid esters and N-acylamino acetals which can easily be carried out on an industrial scale, using readily-obtainable starting materials.
We have found that this object is achieved by a process for preparing N-acyl derivatives of the formula I
in which the substituents independently of one another have the following meanings:
X is CH(OR
3
)
2
, COOR
3
;
R
1
is hydrogen, C
1
-C
12
-alkyl, aryl, unsubstituted or substituted;
R
2
is hydrogen, C
1
-C
12
-alkyl, aryl, unsubstituted or substituted;
R
3
is C
1
-C
12
-alkyl,
which comprises reacting a carboxamide R
1
—CONH
2
of the formula II with a glyoxal monoacetal derivative of the formula III,
 in the presence of a carboxylic acid R
4
—COOH of the formula IV where R
4
=C
1
-C
12
-alkyl, where the substituents R
1
to R
3
are as defined above.
Alkyl radicals for R
1
to R
4
which may be mentioned are branched or straight-chain C
1
-C
12
-alkyl chains, for example methyl, ethyl, n-propyl, 1-methylethyl, n-butyl, 1-methylpropyl, 2 methylpropyl, 1,1-dimethylethyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, 1-ethyl-2-methylpropyl, n-heptyl, n-octyl, 2-ethylhexyl, n-nonyl, n-decyl, n-undecyl and n-dodecyl.
The alkyl chains mentioned above can be unsubstituted, hydroxylated or substituted by mercapto groups. Preferred examples which may be mentioned are hydroxymethyl, hydroxyethyl, such as [CH
3
—CH(OH)— or CH
2
(OH)—CH
2
] or mercaptomethyl radicals.
If the radical X in the formula I is CH(OR
3
)
2
, the substituents R
3
together with the oxygen atoms to which they are attached may also form a 5- or 6-membered ring. Starting materials used in this case are, for example, cyclic glyoxal monoacetals of the general formulae IIIa to IIIc.
Aryl for R
1
and R
2
is to be understood as an aromatic ring or ring system having 6 to 18 carbon atoms in the ring system, for example phenyl or naphthyl, which may be unsubstituted or substituted by one or more radicals, such as halogen, for example fluorine, chlorine or bromine, cyano, nitro, amino, C
1
-C
4
-alkylamino, C
1
-C
4
-dialkylamino, hydroxyl, C
1
-C
4
-alkyl, C
1
-C
4
-alkoxy or other radicals.
Preferred radicals for R
1
are hydrogen and the branched or straight-chain C
1
-C
8
-alkyl chains mentioned in the list above, particularly preferably C
1
-C
3
-alkyl chains. Very particularly preferred radicals for R
1
are hydrogen, methyl and ethyl.
Preferred radicals for R
2
are phenyl and the branched or straight-chain C
1
-C
8
-alkyl chains from the list mentioned above, particularly preferably C
1
-C
3
-alkyl chains. A very particularly preferred radical for R
2
is methyl.
Preferred alkyl radicals for R
3
are the branched or straight-chain C
1
-C
8
-alkyl chains from the list mentioned above, particularly preferably C
3
-C
8
-alkyl chains, such as, for example, n-propyl, 1-methylethyl, n-butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, n-heptyl, n-octyl or 2-ethylhexyl.
Preferred radicals for R
4
are the branched or straigh-chain C
1
-C
8
-alkyl chains from the list mentioned above, particularly preferably C
1
-C
3
-alkyl chains. Very particularly preferred radicals for R
1
are methyl, ethyl, n-propyl and isopropyl.
Depending on the amount of carboxamide R
1
—CONH
2
and carboxylic acid R
4
—COOH employed, the formation of the different N-acyl derivatives of the formula I can be controlled in a targeted manner.
Thus, contrary to expectation, it has been found that reaction of an amount of carboxamide R
1
—CONH
2
and carboxylic acid R
4
—COOH employed of in each case from 250 to 800 mol %, preferably from 400 to 600 mol %, based on the acetal of the formula II employed, gives N-acylamino acid esters of the formula I where X=COOR
3
.
A particularly advantageous embodiment of the process was found to be the use of the carboxamide R
1
—CONH
2
and the carboxylic acid R
4
—COOH in identical molar proportions.
The process according to the invention is particularly suitable for preparing N-formyl-&agr;-aminopropionic acid esters of the formula Ia
in which the substituent R
3
is C
1
-C
8
-alkyl, preferably C
3
-C
8
-alkyl.
Formation of the N-acylamino acetals of the formula I where X=CH(OR
3
)
2
is preferred when the amount of carboxamide R
1
—CONH
2
and carboxylic acid R
4
—COOH employed is in each case from 50 to 250 mol %, preferably from 100 to 200 mol %, based on the acetal of the formula II employed. In this case, too, it is particularly advantageous to employ carboxamide R
1
—CONH2 and carboxylic acid R
4
—COOH in the reaction in a molar ratio of 1:1.
In the case of the N-acylamino acetals of the formula I, the process according to the invention is advantageously suitable for preparing N-formyl-2-aminopropionaldehyde acetals of the formula Ib
in which the substituent R
3
is C
1
-C
8
-alkyl, preferably C
3
-C
8
-alkyl.
The conversion both into the N-acylamino acid esters and into the N-acylamino acetals is carried out at from 40 to 200° C., preferably from 60 to 150° C.
According to the invention, the reaction is carried out in a pressure range of from 200 to 1000 mbar, preferably between 500 and 1000 mbar, particularly preferably at atmospheric pressure.
The reaction can be carried out with or without additional solvent. The reaction is preferably carried out without adding a solvent.
Moreover, the process according to the invention can be carried out advantageously as a “one-pot process”, giving both N-acylamino acid esters and the novel N-acylamino acetals in excellent yields.
The isolation of the desired end product is carried out in a manner known per se. In the case of liquid reaction products, the esters or acetals formed are usually purified by distillation.
The invention also provides N-acyl derivatives of the formula Ic,
in which the substituents independently of one another have the following meanings:
R
1
is hydrogen, C
1
-C
12
-alkyl, aryl, unsubstituted or substituted;
R
2
is hydrogen, C
1
-C
12
-alkyl, aryl, unsubstituted or substituted;
R
3
is C
1
-C
12
-a

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