Preparation of N-9 substituted guanine compounds

Details Preparation of N-9 substituted guanine compounds Preparation of N-9 substituted guanine compounds

1994-08-04

1996-10-15

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

C07D47318

Patent

active

055655653

ABSTRACT:
The invention relates to efficient and selective processes for the synthesis of the antiviral N-9 substituted guanine compounds acyclovir and ganciclovir.

REFERENCES:
patent: 4355032 (1982-10-01), Verheyden et al.
patent: 4360522 (1982-11-01), Schaeffer et al.
patent: 4621140 (1986-11-01), Verheyden et al.
patent: 5250535 (1993-10-01), Verheyden et al.
Vorbruggera, tet. Letters 1978 1339.
Vorbrugger Chem. Ber 114, 1234 (1981).
Kim I, Bull. Korean Chem Soc. 9, 295 (1988).
Kim II, Heterocycles 27, 71 (1988).
Kim III Chemistry Letters 1988, 1045.
Robbins, Nucleosides & Nucleo tides 8, 725-741 (1989).
J. Kjellberg et al., Nucleosides Nucleotides, 8(2), pp. 225-256 (1989).
Zhongguo Yaoke Daxue Xuebao, 23(1), pp. 43-44 (1992).
F. P. Clausen et al., Org. Prep. Proced. Int, 25(4), pp. 375-401 (1993).
H. Matsumoto et al., Chem. Pharm. Bull., 36(3), 1153-1157 (1988).
D. P. C. McGee et al., Synthetic Communications, 18(14), 1651-1660 (1988).
J. C. Martin et al., J. Med. Chem., 26, 759-761 (1983).
"Production of 9-[2-Hydroxyethoxy)methyl]-guanine", Patent Abstracts of Japan, 12: 353 (C-530) [3200] (1988) [abstract of Japanese Patent Kokai No. 107982/1988 (May 1988)].

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