Preparation of multiwall polymeric microcapsules from hydrophili

Details Preparation of multiwall polymeric microcapsules from hydrophili Preparation of multiwall polymeric microcapsules from hydrophili

1995-06-07

1999-11-16

Lovering, Richard D.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

424492, 424493, 424496, 424497, 427 222, 42721331, 42721335, 514963, 514965, A61K 952, B01J 1306, B01J 1320

Patent

active

059853549

ABSTRACT:
Two or more hydrophilic polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to form multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.

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