Preparation of monoclonal antibodies

Details Preparation of monoclonal antibodies Preparation of monoclonal antibodies

1984-06-08

1991-03-19

Tarcza, John E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4351722, 43524027, 435173, 935 93, C12N 1500, C12P 2100, C12N 502, C12N 1300

Patent

active

050010565

ABSTRACT:
A process for selectively producing monoclonal antibodies which comprises selectively bringing together proliferating cells and the appropriate B-cells by means of ligand recognition of respective cell surface receptors and then fusing together the proliferating cells and B-cells thus brought together.

REFERENCES:
patent: 4271145 (1981-06-01), Wands et al.
Bankert et al., "Antigen-Promoted Cell Fusion: Antigen-Coated Myeloma Cells Fuse with Antigen-Reactive Spleen Cells" Transplantation Proceedings, vol. XII, No. 3, pp. 443-446, (1980).
Godfrey et al., "Immunospecific Vesicle Targeting Facilitates Microinjection into Lymphocytes" Proceedings of the National Academy of Sciences, 80, pp. 2267-2271 (1983).
Godfrey et al., "Affinity Homing of Sealed Red Cells Ghosts to Cell Surfaces" Federation Proceedings 39(3), p. 719 Abst. #2387 (1980).
Vienken et al., "Electric Field Induced Fusion: Electro-Hydraulic Procedure for Production of Heterokaryon Cells" Febs Letters 137(12) pp. 11-13 (1982).

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