Preparation of microparticles having improved flowability

Details Preparation of microparticles having improved flowability Preparation of microparticles having improved flowability

2007-07-24

2007-07-24

Venkat, Jyothsna (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S489000

Reexamination Certificate

active

10022859

ABSTRACT:
Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintaining the microparticles at a conditioning temperature for a period of time. The conditioning can be used with microparticles containing an active agent, and with placebo microparticles, and it is reversible.

REFERENCES:
patent: 3523906 (1970-08-01), Vrancken et al.
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 3737337 (1973-06-01), Schnoring et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 3891570 (1975-06-01), Fukushima et al.
patent: 3960757 (1976-06-01), Morishita et al.
patent: 4221862 (1980-09-01), Naito et al.
patent: 4384975 (1983-05-01), Fong
patent: 4389330 (1983-06-01), Tice et al.
patent: 4530840 (1985-07-01), Tice et al.
patent: 4818517 (1989-04-01), Kwee et al.
patent: 4940588 (1990-07-01), Sparks et al.
patent: 5066436 (1991-11-01), Komen et al.
patent: 5407609 (1995-04-01), Tice et al.
patent: 5428024 (1995-06-01), Chu et al.
patent: 5478564 (1995-12-01), Wantier et al.
patent: 5541172 (1996-07-01), Labric et al.
patent: 5650173 (1997-07-01), Ramstack et al.
patent: 5654008 (1997-08-01), Herbert et al.
patent: 5654010 (1997-08-01), Johnson et al.
patent: 5656297 (1997-08-01), Bernstein et al.
patent: 5656299 (1997-08-01), Kino et al.
patent: 5658593 (1997-08-01), Orly et al.
patent: 5667808 (1997-09-01), Johnson et al.
patent: 5688801 (1997-11-01), Mesens et al.
patent: 5747058 (1998-05-01), Tipton et al.
patent: 5770231 (1998-06-01), Mesens et al.
patent: 5792477 (1998-08-01), Rickey et al.
patent: 5871778 (1999-02-01), Kino et al.
patent: 5916598 (1999-06-01), Rickey et al.
patent: 5942253 (1999-08-01), Gombotz et al.
patent: 5945126 (1999-08-01), Thanoo et al.
patent: 5965168 (1999-10-01), Mesens et al.
patent: 0 486 959 (1992-05-01), None
patent: 0831773 (1999-12-01), None
patent: WO 89/03678 (1989-05-01), None
patent: WO 90/13361 (1990-11-01), None
patent: WO 94/10982 (1994-05-01), None
patent: WO 95/13799 (1995-05-01), None
patent: WO 96/40049 (1996-12-01), None
patent: WO 97/41837 (1997-11-01), None
patent: WO 99/12549 (1999-03-01), None
patent: WO 00/40221 (2000-07-01), None
Beck, L.R. et al., Biology of Reproduction, 28:186-195 (Feb. 1983).
Bodmeier, R., et al., International Journal of Pharmaceuticals, 43:179-186 (1988).
Y. Cha and C.G. Pitt, “The Acceleration of Degradation-COntrolled Drug Delivery from Polyester Microspheres,”Journal of Controlled Release, 8 (1989) 259-265.
Y. Cha and C.G. Pitt, “A One-Week Subdermal Delivery System for L-Methadone Based on Biodegradable Microparticles,”Journal of Controlled Release,7 (1988) 69-78.
R. Jalil et al., Journal of Microencapsulation, vol. 7, No. 3, Jul.-Sep. 1990, pp. 297-319.
Wen-I Li et al., Journal of Controlled Release, 37:199-214 (Dec. 1995).
H. V. Maulding et al., “Biodegradable Microcapsules: Acceleration of Polymeric Excipient Hydrolytic Rate by Incorporation of a Basic Medicament,” Journal of Controlled Release, 3:103-117 (Mar. 1986).
Hongkee Sah et al., Pharmaceutical Research, 13:360-367 (Mar. 1996).
Toyomi Sato et al., Pharmaceutical Research, 5:21-30 (1988).
Y. F. Maa et al., “Liquid-liquid emulsification by static mixers for use in microencapsulation,” J. Microencapsulation, 1996, vol. 13, No. 4, 419-433.
B. Conti et al., “Use of polylactic acid for the preparation of microparticulate drug delivery systems,” J Microencapsulation, 1992, vol. 9, No. 2, 153-166.
Amidon, G.E. et al., “Physical Test Methods for Powder Flow Characterization of Pharmaceutical Materials: A Review of Methods,” Pharmacopeial Forum, 25(3):8298-8305 (1999).
Prescott, J.K. & Barnum, R.A., “On Powder Flowability,” Pharmaceutical Technology, 60-84 (2000).
Carr, R.L., Classifying Flow Properties of Solids, Chemical Engineering, 69-72 (Feb. 1, 1965).
Carr, R.L., Evaluating Flow Properties of Solids, Chemical Engineering, 163-168 (Jan. 18, 1965).

Affiliated with

Also associated with

Rating

Preparation of microparticles having improved flowability does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of microparticles having improved flowability, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of microparticles having improved flowability will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3749605