Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-06-14
2011-06-14
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S518000
Reexamination Certificate
active
07960124
ABSTRACT:
A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
REFERENCES:
patent: 02/36490 (2002-05-01), None
patent: 2004/025268 (2004-03-01), None
Devaux, A. et al., “Solubilisation of dye-loaded zeolite L nanocrystals,” Micoporous and Mesoporous Materials 90 (2006) 69-72.
Huber, S. et al., “Sequential Functionalization of the Channel Entrances of Zeolite L Crystals,” Angew. Chem. Int. Ed. 2004, 43, 6738-6742.
Li, H. et al., “Carboxyester funtionalised dye-zeolite L host-guest materials,” Micoporus and Mesoporous Materials 95 (2006) 112-117.
Busby Michael
Calzaferri Gion
De Cola Luisa
Josel Hans-Peter
Popovic Zoran
Cheu Jacob
Roche Diagnostics Operations Inc.
Universitaet Bern
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