Preparation of melt-sprayed spherical phenacetin granules

Details Preparation of melt-sprayed spherical phenacetin granules Preparation of melt-sprayed spherical phenacetin granules

1976-09-07

1978-04-25

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

264 5, 264 13, 264109, 264117, 264123, 264319, 264345, 264349, 424324, A61K 916, A61K 3152, A61K 31165

Patent

active

040863468

ABSTRACT:
Substantially spherical granules of phenacetin are prepared by spraying liquid phenacetin which has been melted without decomposition by means of rapid passage through a melting device in which superheating is minimized. The resultant melt-sprayed granules are superior to crystalline phenacetin in the formulation of pharmaceutical tablets.

REFERENCES:
patent: 3341415 (1967-09-01), Scott
patent: 3388196 (1968-06-01), Farrell
patent: 3439633 (1969-04-01), Pawlak et al.
patent: 3615142 (1971-10-01), Dahlbom
patent: 3698844 (1972-10-01), Grimm
Zaputryaev et al., (1969), Transl. of "The Preparation of Phenacetin Tablets by using Liquefaction", Chem. Abstr. 71 #94721B (1969) of Khimoko-Farmatsevticheskiizhurnal 3(5): 5-54 (1969).
Zaputryaev et al., (1970), Transl. of "Use of Fusion for Preparing Two-Component Tablets Containing Sodium Salts of Organic Acids", Chem. Abstr. 73, #133970v (1970) of Khim-Farmzh 418), 23-26 (1970).
Goodhart et al., J. Pharm. Sci. 62 (1): 133-136 Jan. 1973, Design and Use of a Laboratory Extruder for Pharmaceutical Granulations.
Malinowski et al., J. Pharm. Sci. 63(2): 285-288, Feb. 1974, Effect of Spheronization Process Variables on Selected Tablet Properties.
Jalal et al., J. Pharm. Sci. 61(9): 1466-1468, Sep. 1972, Tablet Granulations Composed of Spherical-Shaped Particles.
Woodruff et al., J. Pharm. Sci. 61(5): 787-790, May 1972, "Effect of Processing Variables on Particles Obtained by Extrusion-Spheronization Processing".
Perry et al., Chemical Engineers Handbook, McGraw-Hill (1973), pp. 10-4-10-10, McKelvey Polymer Processing, Wiley, N.Y. 1967, pp. 288-297.
Weast et al., Handbook of Chem. & Physics, 50th Ed., (1969), Chem. Rubber Cleve. O pp. C74, C78.

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