Preparation of mandelic acid derivatives

Details Preparation of mandelic acid derivatives Preparation of mandelic acid derivatives

2006-04-04

2006-04-04

Parsa, J. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S465000

Reexamination Certificate

active

07022876

ABSTRACT:
A process is provided for the preparation of mandelic acid derivatives. The process comprises the steps of:(a) stereoselectively cyanating a compound of Formula (2) to yield the corresponding cyanohydrin;(b) hydrolyzing the product of step (a) to the corresponding compound of Formula (1).wherein X is a substituent.

REFERENCES:
patent: 5223416 (1993-06-01), Endo et al.
patent: 02/10095 (2002-02-01), None
Belokon et al, Organic Letters, 2(11), pp1617-1619 (2000).
Xiang-Ge et al , J. Chem. Soc. Dalton Trans, pp3303-3309 (1999).
Yaozhong et al, Tetrahedron Letter, 53(42) pp 143237-14338.
Yaozhong et al, Tetrahedron Asymmetry vol. 6(12) pp2915-2916.
Yaozhong, Jiang, et al., “Salen-Ti(OR)4Complex Catalysed Trimethylsilylcyanation of Aldehydes”, Tetrahedron, vol. 53, No. 42, pp. 14327-14338, 1997.
Yaozhong, Jiang, et al., “Asymmetric Synthesis XXVII: Asymmetric Catalytic Trimethylsilylcyanation of Aldehydes by Novel Ti-Chiral Schiff Base Complexes”, Tetrahedron: Asymmetry, vol. 6, No. 12, pp. 2915-2916, 1995.
Belokon, Yuri N., et al, “Vanadium-Catalyzed Asymmetric Cyanohydrin Synthesis”, Organic Letters 2000, vol. 2, No. 11, pp. 1617-1619, 2000.
Zhou, Xiang-Ge, et al, “Titanium and ruthenium binaphthyl Schiff base complexes as catalysts for asymmetric trimethylsilylcyanation of aldehydes”, J. Chem. Soc., Dalton Trans., 1999, pp. 3303-3309.
Belokon et al, J. Am. Chem. Soc., 121(16):3968-3973 (1999).
Mori et al, Comprehensive Asymmetric Catalysis II, Chapter 28; Ed. Jacobsen, Pfaltz, Yamamoto.

Affiliated with

Also associated with

Rating

Preparation of mandelic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of mandelic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of mandelic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3593604