Preparation of lucas reagent of enhanced utility and its use in

Details Preparation of lucas reagent of enhanced utility and its use in Preparation of lucas reagent of enhanced utility and its use in

1997-04-25

1999-01-05

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

570258, C07C 1716

Patent

active

058565973

ABSTRACT:
Gaseous anhydrous hydrogen chloride is introduced into an aqueous solution of zinc chloride under conditions effective to produce a more efficient Lucas reagent than a Lucas reagent made by mixing solid, anhydrous zinc chloride with 38% hydrochloric acid. For example, the reaction rate of such Lucas reagent with levo-menthol is much faster and requires a much shorter reaction period than Lucas reagent formed in the conventional manner from anhydrous, solid zinc chloride and concentrated (38%) hydrochloric acid. Also, the conversion to levo-menthyl chloride was higher when using Lucas reagent formed using gaseous anhydrous hydrogen chloride and aqueous zinc chloride solution. Also, Lucas reagent made in this manner is highly amenable to recycling, and requires only addition thereto of hydrogen chloride to replenish the catalyst for an ensuing run.

REFERENCES:
patent: 4073816 (1978-02-01), Herrmann
Chemistry of Organic Compounds, Carl R. Noller, 1965, Chapter 8, p. 148.

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