Preparation of live attenuated mumps virus for a vaccine

Details Preparation of live attenuated mumps virus for a vaccine Preparation of live attenuated mumps virus for a vaccine

1979-12-06

1982-04-13

Rosen, Sam

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

424 89, C12N 708

Patent

active

043248616

ABSTRACT:
A live attenuated mumps virus vaccine is prepared by cultivating a wild mumps virus strain for 1-18 serial passages in a first living cell to attenuate the virus, and then cultivating the attenuated virus in a second living cell for at least one serial passage to propagate and adapt the virus to the cell. The cell is selected from embryonated hen's egg amnion, embryonated hen's egg chorio-allantoic membrane, chick embryo fibroblast and human diploid cell. Quail embryo fibroblast is also employed. The vaccine prepared has strong immunogenecity and is safe.

REFERENCES:
patent: 3555149 (1971-01-01), Buynak et al.
patent: 3961046 (1976-06-01), Cerini
patent: 4071618 (1978-01-01), Konobe et al.
Purchase et al.-Amer. J. Vet. Research, vol. 32, No. 11 (Nov. 1971), pp. 1811-1823.
Horta-Barbosa et al.-Applied Microbiology, vol. 18, No. 2 (1969), pp. 251-255.

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