Preparation of lipophile:hydroxypropylcyclodextrin complexes by

Details Preparation of lipophile:hydroxypropylcyclodextrin complexes by Preparation of lipophile:hydroxypropylcyclodextrin complexes by

1990-09-20

1992-06-09

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, A61K 918, C08B 3716

Patent

active

051207206

ABSTRACT:
The dissolution of lipophilic compounds in aqueous solutions of hydroxypropylcyclodextrins can be accelerated by the addition of co-solubilizers, such as ethanol or ammonia, which again can be removed, together with water, by evaporation or by freeze-drying leaving lipophile: hydroxypropylcyclodextrin complexes as a residue. The co-solubilizer method was used successfully with steroid drugs (5-androstene-3.beta.,17.beta.-diol, 4-androstene-3,17-dione, dehydroepiandrosterone, dexamethasone, 5-.alpha.-dihydro-testosterone, 6-methylprednisolone, and testosterone), peptides (gramicidin S) and a macrocyclic antibiotic (amphotericin B). The complexes prepared in this manner were amorphous and possessed satisfactory stability.

REFERENCES:
patent: 4727064 (1988-02-01), Pitha
patent: 4877774 (1989-10-01), Pitha et al.
patent: 4877778 (1989-10-01), Carpenter et al.
patent: 5024997 (1991-06-01), Motola et al.
Anaissie et al., U.S. patent application SN 07/345,928.
Kurozumi et al., Chem. Pharm. Bull., 23 (12) pp. 3062-3068 (1975).
Vikmon, M. et al., J. Antibiot., vol. 38, pp. 1822-1824 (1985).
Pitha et al., Internatl. Journ. of Pharmaceutics, vol. 29, pp. 73-82 (1986).
Torres-Labandeira et al., J. Pharm. Sci., vol. 80, No. 4, pp. 384-386 (Apr. 1990).
Kajtar et al., Biopolymers, vol. 28, pp. 1585-1596 (1989).
W. Hirsch et al., Can. J. Chem., vol. 65, pp. 2661-2664 (1987).
R. I. Gelb et al., J. Am. Chem. Soc., vol. 104, pp. 6283-6288 (1982).
T. Cserhati et al., Journal of Chromatography, vol. 259, pp. 107-110 (1983).

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