Preparation of lipid-nucleic acid particles using a solvent extr

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...

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435 911, 435 9131, 435325, 4353201, 424 932, 424450, 264 41, 935 52, 935 54, 536 231, 536 245, 514 44, C12N 1588, A61K 9127, A61K 4800, B01J 1302, B01J 1304, C07H 2104

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06110745&

ABSTRACT:
This invention relates to a novel Solvent Extraction and Direct Hydration (SEDH) method for preparing lipid-nucleic acid particles which are useful for the introduction of nucleic acids (e.g., plasmid DNA, antisense molecules, ribozymes, etc.) into cells. The lipid-nucleic acid particles prepared using the methods of the present invention have enhanced circulation characteristics and serum stability and, thus, they are extremely effective as nucleic acid delivery vehicles.

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patent: 5705385 (1998-01-01), Bally et al.
Andrea D. Branch, A good antisense molecule is hard to find, TIBS, 47-48, Feb. 1998.
Trisha Gura, Antisense Has Growing Pains, Science, pp. 575-577, Oct. 1995.
Stanley Crooke, Antisense '97: A roundtable on the state of the industry, Nature Biotechnology, p. 522, Jun. 1997.
Stanley Crooke, Antisense Research and Applications, Chapter 1, Basic Principles of Antisense Therapeutics, Springer-Verlag Press, Berlin, Heidelberg, New York, p. 3, Jul. 1998.
Chonn, et al., Current Opinion in Biotechnology, 6(6):698-708 (1995).

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