Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1998-07-23
2000-08-29
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435 911, 435 9131, 435325, 4353201, 424 932, 424450, 264 41, 935 52, 935 54, 536 231, 536 245, 514 44, C12N 1588, A61K 9127, A61K 4800, B01J 1302, B01J 1304, C07H 2104
Patent
active
06110745&
ABSTRACT:
This invention relates to a novel Solvent Extraction and Direct Hydration (SEDH) method for preparing lipid-nucleic acid particles which are useful for the introduction of nucleic acids (e.g., plasmid DNA, antisense molecules, ribozymes, etc.) into cells. The lipid-nucleic acid particles prepared using the methods of the present invention have enhanced circulation characteristics and serum stability and, thus, they are extremely effective as nucleic acid delivery vehicles.
REFERENCES:
patent: 5283185 (1994-02-01), Epand et al.
patent: 5705385 (1998-01-01), Bally et al.
Andrea D. Branch, A good antisense molecule is hard to find, TIBS, 47-48, Feb. 1998.
Trisha Gura, Antisense Has Growing Pains, Science, pp. 575-577, Oct. 1995.
Stanley Crooke, Antisense '97: A roundtable on the state of the industry, Nature Biotechnology, p. 522, Jun. 1997.
Stanley Crooke, Antisense Research and Applications, Chapter 1, Basic Principles of Antisense Therapeutics, Springer-Verlag Press, Berlin, Heidelberg, New York, p. 3, Jul. 1998.
Chonn, et al., Current Opinion in Biotechnology, 6(6):698-708 (1995).
Hope Michael J.
Scherrer Peter
Zhang Yuan-Peng
Epps Janet
Inex Pharmaceuticals Corp.
Schwartzman Robert A.
LandOfFree
Preparation of lipid-nucleic acid particles using a solvent extr does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation of lipid-nucleic acid particles using a solvent extr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of lipid-nucleic acid particles using a solvent extr will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1248896