Preparation of levofloxacin and hemihydrate thereof

Details Preparation of levofloxacin and hemihydrate thereof Preparation of levofloxacin and hemihydrate thereof

2002-10-03

2009-12-08

Habte, Kahsay T (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S099000

Reexamination Certificate

active

07629458

ABSTRACT:
The invention provides a method for preparing levofloxacin hemihydrate, comprising:maintaining levofloxacin at a first elevated temperature in a first solvent;adding a polar solvent to precipitate the levofloxacin hemihydrate, wherein the polar solvent comprises water; andrecovering the levofloxacin hemihydrate.The invention also provides a method of converting a levofloxacin form to levofloxacin hemihydrate, comprising storing one or more forms selected from the group consisting of Forms A, B, C, F, G and H for a sufficient time to permit the one or more forms to convert to levofloxacin hemihydrate.

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