Preparation of large crystals of N-benzyloxycarbonyl-L-aspartic

Details Preparation of large crystals of N-benzyloxycarbonyl-L-aspartic Preparation of large crystals of N-benzyloxycarbonyl-L-aspartic

1983-08-26

1986-02-11

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C12506

Patent

active

045700150

ABSTRACT:
N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) crystals several times larger than those obtained by conventional crystallization are prepared by acidifying an alkaline aqueous solution of a metal salt of Z-Asp at high temperatures of between about 20.degree. to 45.degree. C. The resulting large crystals contain less moisture and less impurities such as sodium chloride, dipeptide and benzyl alcohol, etc. than those crystals obtained at lower temperatures and they are easily processed for preparing aspartame.

REFERENCES:
patent: 3808190 (1974-04-01), Dahlmans
patent: 4293706 (1981-10-01), Gorman
patent: 4345091 (1982-08-01), Sugiyama
patent: 4450284 (1984-05-01), Sathe
Kirk-Othmer, "Encyclopedia of Chemical Technology," vol. 6, pp. 482-514 (1965).

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