Preparation of lactones

Details Preparation of lactones Preparation of lactones

1985-07-26

1987-06-30

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260408, 2604105, 2604109R, 548406, 549214, 549292, 549407, 549417, 549209, 556437, 560 56, 560 59, 560 60, 562466, C07F 708, C07F 718, C07C 6976

Patent

active

046772111

ABSTRACT:
7-Substituted lower alkyl hept-6-enoates and 4-hydroxytetrahydropyran-2-ones bearing 6-olefinic substituents (e.g.,) ethyl erythro-3,5-dihydroxy-7-phenyl-hept-6-enoates are prepared by a multi-step process. The process involves 3-protected-lower alkyl 3,5-dihydroxy-hept-6-enoates, which are obtained by cleaving corresponding 6.alpha.-vinyl-4.beta.-protected hydroxy-tetrahydro 2H-pyran-2-ones. The final products are useful as anti hypercholesteremic agents.

REFERENCES:
patent: 3637721 (1972-01-01), Pappas
patent: 4420491 (1983-12-01), Albers-Schonberg
patent: 4450171 (1984-05-01), Hoffman
Maercker, "Organic Reactions," vol. 14, pp. 270-377, John Wiley & Sons, Inc., (1965).
Reese, "Protective Groups in Organic Chemistry," pp. 95, 103 & 104, Plenum Press, (1973).

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