Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstitute

Details Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstitute Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstitute

1981-09-22

1984-05-08

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544151, 544376, 546196, 549406, C07D40512, C07D31174

Patent

active

044476221

ABSTRACT:
The laevo and dextro forms of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and similar derivatives thereof have substantially double the post-coital anti-fertility activity of the known racemic compound. The resolution of such known compound into the l- and d-isomeric forms may be carried out using di-p-toluoyl-l-tartaric acid monohydrate or di-p-toluoyl-d-tartaric acid.

REFERENCES:
patent: 4251537 (1981-02-01), Evans
Eliel, Stereochemistry of Carbon Compounds, McGraw-Hill, New York, (1962), pp. 49 & 50.

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