Preparation of isoflurane

Details Preparation of isoflurane Preparation of isoflurane

1991-09-30

1995-05-16

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

20415792, C07C 4100

Patent

active

054162440

ABSTRACT:
An improved process for the production of isoflurane is disclosed. Isoflurane is formed by the exhaustive chlorination of 2,2,2-trifluoroethyl difluoromethyl ether with chlorine gas. The reaction mixture, preferably without purification or refining, is treated with UV light in the presence of isopropanol to reduce 1,1-dichloro-2,2,2-trifluoroethyl difluoromethyl ether, the other major component thereof, to isoflurane. Isoflurane is thereby obtained in yields of at least 80%.

REFERENCES:
patent: 3535388 (1970-10-01), Terrell
patent: 3535425 (1970-10-01), Terrell
patent: 4720587 (1973-03-01), Croix
Dedek et al., Purification of 2-chloro-1,1,2-trifluoroethyl dufluoronmethyl ether, ca, 06 (1): 4523c, 1986.
Paleta et al.-J. Fluorine Chemistry, vol. 39, (1988), pp. 397-414 (I).
Paleta et al.-Bulletin de La Societe Chimique De France, vol. 6, (1986), pp. 920-924 (II).
Paleta et al.-Collection Czechoslovak Chem. Commun., vol. 48, (1983), pp. 766-771 (III).

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