Preparation of islet amyloid polypeptides (IAPP) and antibodies

Details Preparation of islet amyloid polypeptides (IAPP) and antibodies Preparation of islet amyloid polypeptides (IAPP) and antibodies

1991-02-21

1992-05-12

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530303, 530327, 530845, C07K 740, C07K 710

Patent

active

051129450

ABSTRACT:
Subunits of the full length 37 amino acid residue human Islet Amyloid Polypeptide, and feline Islet Amyloid Polypeptide essentially free of unpolymerized amyloid are provided. Islet Amyloid Polypeptide (IAPP) may be isolated and purified from amyloid fibrils using depolymerizing agent and chromatographic techniques. The sequences of the purified Islet Amyloid Polypeptides have been determined Purified Islet Amyloid Polypeptides are suitable for induction of anti-IAPP antibodies.

REFERENCES:
Cooper, G. J. S. et al. PNAS 84:8628, Dec. 1987, "Purification and characterization . . .".
Mosselman, S. et al. FEBS Lett. 247(1):154-158 Apr. 1989 "The complete islet amyloid . . .".
Marglin, A. and R. B. Merrifield Chemical Synthesis of Peptides, 1970.
Westermark, P. et al. 1983, Diabetologia 24:342-346, Islet Amyloaid in Type 2 . . . .
Fang, T. Y. et al. 1986, Pancreas 1(4):293-300, Immunohistochemical study . . . (see abstract).
C. Betsholtz et al., Exper. Cell Res., 183, 484 (1989).
T. D. O'Brien, Am. J. Pathol., 119, 430 (1985).
K. H. Johnson et al., Vet. Pathol., 22, 463 (1985).
K. Higuchi et al., Lab. Invest., 48, 231 (1983).
C. Betsholtz et al., Diabetes, 39, 118 (1990).

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