Preparation of intravenous human and animal gamma globulins and

Details Preparation of intravenous human and animal gamma globulins and Preparation of intravenous human and animal gamma globulins and

1977-08-31

1979-01-23

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 424101, 424177, A23J 106, A61K 3704

Patent

active

041360940

ABSTRACT:
A method of isolating and purifying natural, unaltered, undenatured immune gamma globulin (IgG) for intravenous administration and albumin from animal blood plasma, especially human, and the resulting products. The method involves the initial stabilization of plasma by treatment with silica, or the use of previously stabilized plasma. IgG and albumin are isolated from the stabilized plasma by chromatographic reaction with sterile ion exchange resin and eluted by adjustment of pH and ionic strength. The products are concentrated, purified further and packaged. They are characterized by high yield and high purity. They are unfragmented and unaggregated, i.e., natural preparation.

REFERENCES:
patent: 3686395 (1972-08-01), Stephan
patent: 3763135 (1973-10-01), Shanbrom et al.
patent: 3869436 (1976-03-01), Falksveden
patent: 3903262 (1975-09-01), Pappenhagen et al.
patent: 3916026 (1975-10-01), Stephan
patent: 3966906 (1976-06-01), Schultze et al.
patent: 3998946 (1976-12-01), Condie et al.
patent: 4025500 (1977-05-01), Garcia et al.

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