Preparation of intermediates useful in the synthesis of quinolin

Details Preparation of intermediates useful in the synthesis of quinolin Preparation of intermediates useful in the synthesis of quinolin

1997-07-07

2000-05-02

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564282, 564291, C07D20952, C07C21100

Patent

active

060574550

ABSTRACT:
A process for preparing a compound of the formula ##STR1## wherein R.sup.1, m, o and p are described below, which comprises adding a base of the formula ##STR2## wherein R.sup.2, R.sup.3 and R.sup.4 are as described below, to a solution comprising a compound of the formula ##STR3## wherein R.sup.1, m, o and p are as described below, and a halonitromethane of the formula O.sub.2 NCH.sub.2 X, wherein X is a halogen atom dissolved in a non-aqueous inert solvent. The compounds of formula III are useful as intermediates in the syntheses of azabicyclo quinoline carboxylic acids, and their pharmaceutically acceptable salts and prodrugs, having antibacterial activity. This invention also relates to the base of formula IV wherein each R.sup.2 is butyl, R.sup.3 is hydrogen and each R.sup.4 is t-butyl.

REFERENCES:
patent: 5256791 (1993-10-01), Braish
patent: 5298629 (1994-03-01), Braish

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