Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-10-04
1991-12-10
Scalzo, Catherine S. Kilby
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
544105, C07D21142
Patent
active
050719904
ABSTRACT:
A process for the preparation of N-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidines of the formula ##STR1## which comprises reacting a compound of the formula ##STR2## with glyoxal of the formula ##STR3## in a solvent to give the addition product ##STR4## and reducing such addition product (II) with a hydrogen donor reducing agent to produce the intermediates of the formula and then the end product (I).
REFERENCES:
patent: 3759929 (1973-09-01), Klotmann et al.
patent: 4940705 (1990-07-01), Boshagen et al.
Patent Abstracts of Japan, Band 3, Nr. 128 (C-62), 24, 10/79; & JP A-54 106 477 (Nippon Shinyaku) 21-8-1979.
Synthesis, Nr. 10, Oct. 1987, pp. 917-919; N. Farfan et al.
Bayer Aktiengesellschaft
Kilby Scalzo Catherine S.
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