Preparation of insulin conjugates

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides

Reexamination Certificate

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C530S345000

Reexamination Certificate

active

07977454

ABSTRACT:
The present invention discloses a process for making an insulin-oligomer conjugate as a one-pot reaction by conjugation of insulin-ester with an activated oligomer wherein simultaneous deblocking and conjugation is carried out.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4343898 (1982-08-01), Markussen
patent: 5359030 (1994-10-01), Ekwuribe et al.
patent: 6309633 (2001-10-01), Ekwuribe et al.
patent: 6828297 (2004-12-01), Ekwuribe et al.
patent: 7166571 (2007-01-01), Soltero et al.

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