Preparation of injectable doxorubicin/liposome suspension

Details Preparation of injectable doxorubicin/liposome suspension Preparation of injectable doxorubicin/liposome suspension

1987-05-18

1990-05-22

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

424450, 4284022, 436829, 514893, 514894, 514908, A61K 3722, A61K 4505, B01J 1302

Patent

active

049275712

ABSTRACT:
An doxorubicin/lyposome composition which can be reconstituted from a lyophilized form to an injectable liposome suspension having selected liposome sizes in the size range between 0.1 and 0.5 microns, and between about 85-95% liposome-entrapped doxorubicin. The composition is prepared by reconstituting a lyophilized doxorubicin/liposome composition to a liposome concentrate, then diluting the concentrate for perenteral.

REFERENCES:
patent: 4460577 (1984-07-01), Moro et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4687762 (1987-08-01), Fukushima et al.
patent: 4797285 (1989-01-01), Barenholz et al.

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