Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1985-10-07
1987-09-15
Rose, Shep K.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
424 89, 424 90, A61K 3912
Patent
active
046939814
ABSTRACT:
Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.
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Creagan Richard P.
Giles Richard
Stevens David R.
Wiesehahn Gary P.
Advanced Genetics Research Institute
Rose Shep K.
Rowland Bertram I.
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