Preparation of imidazoles

Details Preparation of imidazoles Preparation of imidazoles

1982-05-10

1983-10-11

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544316, 544333, 546278, 548137, 548152, 548178, 548179, 548180, 548186, 548187, 548189, 548202, 548207, 548209, 548213, 548214, 548335, 548336, C07D23364, C07D23358

Patent

active

044093896

ABSTRACT:
Disclosed is a novel process and product involving the manufacture in advantageously high yields of imidazole compounds corresponding to the general formula: ##STR1## wherein a preferred embodiment of the process comprises contacting a diamine salt of the formula ##STR2## with a biscarbonyl compound of the structure ##STR3## in an acid medium, wherein R, R.sub.1 and R.sub.2 each represents hydrogen or any group which does not hinder the cyclization reaction or lead to degradation of the reactants or imidazole products, and A.sup.- is an anion equivalent such as that of mineral acids, sulfonic acids and carboxylic acids.

REFERENCES:
Davidson, D., et al., J. Org. Chem., 2, 319, (1937).
Smith, P., The Chemistry of Open-Chain Organic Nitrogen Compounds, vol. I, W. A. Benjamin, N.Y., 1965, p. 329.
Knudsen, P., Berichte, 2698, (1914).
Lednicer, D., et al., The Organic Chemistry of Drug Synthesis, Wiley-Interscience, New York, 1977, vol. 1, pp. 238-241 and vol. 2, pp. 242-249.
Noller, C., Chemistry of Organic Compounds, W. B. Saunders, Philadelphia, 1965, p. 523.

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