Preparation of homogeneous hydrogel copolymers

Details Preparation of homogeneous hydrogel copolymers Preparation of homogeneous hydrogel copolymers

1990-12-03

1993-11-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 264310, 264311, 264255, 264267, 523526, 604 59, A61M 5178

Patent

active

052663256

ABSTRACT:
A method is provided for the preparation of homogeneous copolymers having a redetermined equilibrium water content (EWC) value formed by the addition polymerization of a mixture of ethylenically unsaturated monomer A and ethylenically unsaturated monomer B, for example, 2-hydroxyethyl methacrylate and hydroxypropyl methacrylate. The method requires determining the EWC values of the hydrogel homopolymer of hydrophilic monomer A (homopolymer A) and the hydrogel homopolymer of hydrophilic monomer B (homopolymer B); determining the relationship of the EWC values of the homogeneous copolymers AB versus the chemical composition of said copolymers AB; selecting the targeted EWC value and determining the chemical composition of copolymer AB having the targeted EWC value; forming a polymerizable mixture of monomer A and monomer B in amounts sufficient to yield copolymer AB having the targeted EWC value; and effect the polymerization reaction to yield copolymer AB characterized by the targeted EWC value. A method is also provided for the preparation of a delivery device including a drug contained in the reservoir of the hydrogel of copolymer AB, said device being characterized by its capability of eluting or releasing the drug through the hydrogel membrane to a delivery environment at a predetermined rate. There is also disclosed a sterilized kit containing a trocar or hypodermic needle/syringe and the aforesaid drug delivery device having a cylindrical shape with a rounded or bullet-like extremity.

REFERENCES:
patent: 2513014 (1950-06-01), Fields
patent: 3921632 (1975-11-01), Bardani
patent: 4846793 (1989-07-01), Leonard
patent: 4871094 (1988-04-01), Gall
patent: 4959217 (1990-09-01), Sanders
patent: 4994028 (1991-02-01), Leonard
patent: 5004614 (1991-04-01), Staniforth
patent: 5035891 (1991-07-01), Runk et al.

Affiliated with

Also associated with

Rating

Preparation of homogeneous hydrogel copolymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of homogeneous hydrogel copolymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of homogeneous hydrogel copolymers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2093870