Preparation of heterocyclic-cyclohexanedione derivatives

Details Preparation of heterocyclic-cyclohexanedione derivatives Preparation of heterocyclic-cyclohexanedione derivatives

1991-12-18

1993-09-14

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546344, 549 13, 549427, 568 43, 568 13, 568329, 568340, 568376, 568427, C07D30902, C07D33502, C07D33516, C07D21344

Patent

active

052450414

ABSTRACT:
A process for the preparation of cyclohexanedione derivatives of the general formula I ##STR1## where R.sup.1 is C.sub.2 -C.sub.8 -alkyl, C.sub.2 -C.sub.8 -alkenyl, C.sub.3 -C.sub.12 -cycloalkyl, C.sub.5 -C.sub.12 -cycloalkyl with 0-4 olefinically unsaturated bonds, C.sub.2 -C.sub.8 -alkylthioalkyl, C.sub.6 -C.sub.12 -bicycloalkyl with 0-3 olefinically unsaturated bonds, unsubstituted or substituted aryl or hetaryl, or a heterocyclic radical of 4 to 7 atoms of which not more than 3 may be hetero-atoms chosen from O, S and N, the radical being saturated or olefinically unsaturated, by reacting an .alpha.,.beta.-unsaturated ketone (II) with a dialkyl malonate in the presence of a base to give the alkoxycarbonylcyclohexenolone or its salt (III) ##STR2## and acylation, hydrolysis and decarboxylation of (III), wherein the .alpha.,.beta.-unsaturated ketone (II) is reacted, in the presence of a base, with the dialkyl malonate in a solvent from which the alcohol liberated from the malonate can be distilled off, the alcohol is distilled off, where appropriate as an azeotrope, the salt of the alkoxycarbonylcyclohexenolone is reacted with a carboxylic acid halide and the product, where appropriate after removal of excess acyl halide, is treated with an acylation catalyst, hydrolyzed and decarboxylated.

REFERENCES:
patent: 3950420 (1976-04-01), Sawaki et al.
patent: 4115204 (1978-09-01), Murtha
patent: 5006158 (1991-04-01), Carter et al.

Affiliated with

Also associated with

Rating

Preparation of heterocyclic-cyclohexanedione derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of heterocyclic-cyclohexanedione derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of heterocyclic-cyclohexanedione derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2028148