Preparation of hemoproteins from apoproteins and heme-like porph

Details Preparation of hemoproteins from apoproteins and heme-like porph Preparation of hemoproteins from apoproteins and heme-like porph

1996-06-06

1998-06-23

Witz, Jean C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

514 6, 540145, 530385, C12P 2104, A61K 3816, A61K 3514, C07B 4700

Patent

active

057704040

ABSTRACT:
Hemin-like porphyrins can be prepared from chlorophylls which may be used as intermediates to form functionally active hemoproteins. The porphyrins can be reacted with apoproteins in vitro or added to a cell culture and combined intracellularly with apoproteins to form functionally active hemoproteins.

REFERENCES:
Siefermann-Harms et al. "Reassembly of solubilized chlorophyll-protein complexes in proteolipid particles-comparison of monogalactosyldiacylgyl and two phospholipids", Biochim. Biophys. Acta (1987) 892: 303-313.
Brady et al. General Chemistry, 2nd. edition. (Wiley: New York) (1978) pp. 362-363.
Antonini et al. "Studies on the structure of hemoglobin III. Physicochemical properties of reconstituted hemoglobins", Biochim. Biophys. Acta (1964) vol. 79, pp. 284-292.
Tavill et al. "The role of heme in the synthesis and assembly of hemoglobin", J. Biol. Chem. (1968) vol. 243(19), pp. 4987-4999.
Kephart, "Chlorophyll Derivatives--Their Chemistry, Commercial Preparation and Uses", Economic Botany pp. 3-38. vol. 9 (1955).
Dougherty et al. "Journal of the American Chemical Society", vol. 88, No. 21, (1966) pp. 5307-5308.
Smith et al., "New Efficient Total Syntheses of Derivatives of Protoporphyrin-1X", Journal of Heterocyclic Chemistry, vol. 20, No. 5, (1983) pp. 1383-1388.
Smith et al., "Syntheses of Isomers of Protoporphyrin-1X: With Permuted Propionic Side-Chains" Journal of Heterocyclic Chemistry, vol. 22, No. 4, (1985) pp. 1041-1044.
Fanelli et al., "Studies on the Structure of Hemoglobin: Physicochemical Properties of Human Globin" Biochemica Biophysica Acta, vol. 30, No. 3, (1958) pp. 608-615.

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