Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-09-16
1994-03-08
Naff, David M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435212, 4352571, 435946, 548418, 548425, C07D20956, C12P 1716, C12P 1718, C12P 1710
Patent
active
052926508
ABSTRACT:
New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
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R. E. Schwartz et al., "Unusual Cyclopropane-Containing Hapalindolinones from a Cultured Cyanobacterium", J. Org. Chem. 52, 3704-3706 (1987).
R. E. Moore et al., "Hapalindoles: New Alkaloids from the Blue-Green Alga Hapalosiphon fontinalis", J. Am. Chem. Soc. 106, 6456-6457 (1984).
R. E. Moore et al., "Hapalindoles, Antibacterial and Antimycotic Alkaloids from the Cyanophyte Hapalosiphon fontinalis", J. Org. Chem. 52, 1036-1043 (1987).
F. Valeriote et al., "Discovery of Anticancer Agents from Natural Products in a New In Vitro Screen," Intern. Res. Congress on Natural Products, Chicago, Ill., Jul. 21-26, 1991.
F. Valeriote et al., "Discovery of Anticancer Activities in Blue-Green Algae and Marine Organisms," Proc. Am. Assn. Cancer Res. 32, 402 (1991).
Smitka, et al., J. Org. Chem., 57:857-861, 1992.
Bonjouklian Roseanne
Moore Richard E.
Patterson Gregory M. L.
Smitka Tim A.
Eli Lilly and Company
Fontana Steven A.
Lankford L. Blaine
Naff David M.
University of Hawai'i
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