Preparation of granules containing salinomycin

Details Preparation of granules containing salinomycin Preparation of granules containing salinomycin

1994-08-19

1996-06-25

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

426807, 435119, 435123, 435804, C12P 1716, C12P 1718, C12P 1702

Patent

active

055299113

ABSTRACT:
Granules containing salinomycin are prepared that are free-flowing, dust-free, and have unrestricted bioavailability of salinomycin. The granules are produced by fermenting a culture broth with a salinomycin producing microorganism to a residual fat content of about 24 to 30% by dry weight broth, adding to the fermented broth a cellulose ether and an anticaking agent, and spray drying the broth while adding a flow auxiliary to produce granules containing 10 to 26% by weight salinomycin. The granules also contain, based on the weight of the broth being fermented, 30 to 40% anticaking agent and flow auxiliary in a ratio of 3:1 to 9:1 and 0.5 to 2% cellulose ether. The anticaking agent is preferably a calcium carbonate such as chalk or a silica of natural origin such as diatomaceous earth, talc, or kaolin. The flow auxiliary is preferably a synthetic or precipitated silica.

REFERENCES:
patent: 4233405 (1980-11-01), Neubeck
patent: 4395491 (1983-07-01), Hohl et al.
patent: 4824829 (1989-04-01), Klothen
patent: 4876198 (1989-10-01), Markussen

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