Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Reexamination Certificate
2005-09-06
2005-09-06
Hartley, Michael (Department: 1616)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
C424S489000, C424S493000, C424S496000, C424S499000, C424S500000, C516S011000, C516S077000
Reexamination Certificate
active
06939530
ABSTRACT:
Microspheres are prepared by a process comprising (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microspheres have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 μm, targeted to selected areas of the body or of prolonged life in the circulation.
REFERENCES:
patent: 2797201 (1957-06-01), Veatch et al.
patent: 3501419 (1970-03-01), Bridgeford
patent: 3565559 (1971-02-01), Sato et al.
patent: 3781230 (1973-12-01), Vassiliades et al.
patent: 3960583 (1976-06-01), Netting et al.
patent: 4089800 (1978-05-01), Temple
patent: 4102806 (1978-07-01), Kondo et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4127622 (1978-11-01), Watanabe et al.
patent: 4173488 (1979-11-01), Vassiliades et al.
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4316391 (1982-02-01), Tickner
patent: 4420442 (1983-12-01), Sands
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4500676 (1985-02-01), Balazs et al.
patent: 4718433 (1988-01-01), Feinstein
patent: 4774958 (1988-10-01), Feinstein
patent: 4844882 (1989-07-01), Widder et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4904479 (1990-02-01), Illum
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4960351 (1990-10-01), Kendall, Jr. et al.
patent: 4968562 (1990-11-01), Delgado
patent: 4981625 (1991-01-01), Rhim et al.
patent: 5069936 (1991-12-01), Yen
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5190982 (1993-03-01), Erbel et al.
patent: 5196183 (1993-03-01), Yudelson et al.
patent: 5205287 (1993-04-01), Erbel et al.
patent: 5215680 (1993-06-01), D'Arrigo
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5370861 (1994-12-01), Klaveness et al.
patent: 5380519 (1995-01-01), Schneider et al.
patent: 5425366 (1995-06-01), Reinhardt et al.
patent: 5498421 (1996-03-01), Grinstaff et al.
patent: 5501863 (1996-03-01), Rossling et al.
patent: 5536490 (1996-07-01), Klaveness et al.
patent: 5543162 (1996-08-01), Timonen et al.
patent: 5547656 (1996-08-01), Unger
patent: 5567413 (1996-10-01), Klaveness et al.
patent: 5567414 (1996-10-01), Schneider et al.
patent: 5605673 (1997-02-01), Schutt et al.
patent: 5643553 (1997-07-01), Schneider et al.
patent: 5658551 (1997-08-01), Schneider et al.
patent: 5674468 (1997-10-01), Klaveness et al.
patent: 5741478 (1998-04-01), Osborne et al.
patent: 5863554 (1999-01-01), Illum
patent: 5955108 (1999-09-01), Sutton et al.
patent: 5957848 (1999-09-01), Sutton et al.
patent: 5961459 (1999-10-01), Kaul et al.
patent: 5993805 (1999-11-01), Sutton et al.
patent: 6015546 (2000-01-01), Sutton et al.
patent: 6017310 (2000-01-01), Johnson et al.
patent: 6022525 (2000-02-01), Sutton et al.
patent: 6066340 (2000-05-01), Callegaro et al.
patent: 6068600 (2000-05-01), Johnson et al.
patent: 6071496 (2000-06-01), Stein et al.
patent: 6177062 (2001-01-01), Stein et al.
patent: 6264918 (2001-07-01), Johnson et al.
patent: 6264959 (2001-07-01), Stein et al.
patent: 6344182 (2002-02-01), Sutton et al.
patent: 6348186 (2002-02-01), Sutton et al.
patent: 6416741 (2002-07-01), Sutton et al.
patent: A-80297/91 (1992-01-01), None
patent: 2036107 (1991-08-01), None
patent: 0 052 575 (1982-05-01), None
patent: 0 091 555 (1983-10-01), None
patent: 0 131 540 (1985-01-01), None
patent: 0 224 934 (1987-06-01), None
patent: 0 324 938 (1989-07-01), None
patent: 0 327 490 (1989-08-01), None
patent: 0 381 543 (1990-08-01), None
patent: 0 458 079 (1991-11-01), None
patent: 0 458 745 (1991-11-01), None
patent: 0 494 615 (1992-07-01), None
patent: 0 554 213 (1993-08-01), None
patent: 0 606 486 (1994-07-01), None
patent: 0 611 567 (1994-08-01), None
patent: 2660864 (1991-10-01), None
patent: 1 288 583 (1972-09-01), None
patent: 56-129035 (1981-10-01), None
patent: 4-145131 (1992-05-01), None
patent: 4-506931 (1992-12-01), None
patent: 6-507884 (1994-09-01), None
patent: 227869 (1992-11-01), None
patent: WO 84/02838 (1984-08-01), None
patent: WO 90/13780 (1990-11-01), None
patent: WO 91/06282 (1991-05-01), None
patent: WO 91/06286 (1991-05-01), None
patent: WO 91/09629 (1991-07-01), None
patent: WO 91/12823 (1991-09-01), None
patent: WO 91/15244 (1991-10-01), None
patent: WO 91/16080 (1991-10-01), None
patent: WO 92/05806 (1992-04-01), None
patent: WO 92/17212 (1992-10-01), None
patent: WO 92/17213 (1992-10-01), None
patent: WO 92/18164 (1992-10-01), None
patent: WO 93/02712 (1993-02-01), None
patent: 01 89/0873 (1989-02-01), None
Haghpanah, M., et al., abstract presented at British Pharmaceutical Conference, King's College, London (1991).
Aldrich, J.E. and Johnston, J.R., “Use of the Spinning Disk Technique to Produce Monodisperse Microspheres of Human Serum Albumin for Labelling with Radioisotopes,”Int. J. Appl. Radiat. Isotopes25:15-18, Pergamon Press (1974).
Barnhart, J., et al., “Characteristics of Albunex: Air-Filled Albumin Microspheres for Echocardiography Contrast Enhancement,”Invest. Radiol.25:S162-S164, Lippicott, Williams & Wilkins (1990).
Basu, S. and Bhattacharya, G., “Some Aspects of the Phenomenon of Coacervation,”Science115:544-545, American Association for the Advancement of Science (1952).
Baveja, S. K. et al., “Microencapsulation of soluble pharmaceuticals,”J. Microencapsulation3(1):33-37, Taylor & Francis (1986).
Beller, G. A. et al., “Assessment of Regional Myocardial Perfusion by Positron Emission Tomography after Intracoronary Administration of Gallium-68 Labeled Albumin Microspheres,”J. Computer Assisted Tomography3(4):447-452, Lippicott, Williams & Wilkins (1979).
Cheng, K. T. et al., “The Production and Evaluation of Contrast-Carrying Liposomes Made with an Automatic High-Pressure System,”Invest. Radiol.22(1):47-55, Lippincott, Williams & Wilkins (1987).
Clausen, G. et al., “Distribution of blood flow in the dog kidney. III. Local uptake of 10 μm and 15 μm microspheres during renal vasodilation and constriction,”Acta Physiol. Scand.113:471-479, Blackwell Scientific Publications (1981).
Conte, U. et al., “Spray Dried Albumin Microspheres Containing Nicardipine,”Eur. J. Pharm. Biopharm.40(4):203-208, Elsevier Science (Aug. 1994).
Cremers, H. F. M. et al., “Albumin-Heparin Microspheres As Carriers for Cytostatic Agents,”J. Controlled Release11:167-179, Elsevier Science Publishers (1990).
Davis, S. S. and Illum, L., “Microspheres As Drug Carriers,” in:Drug Carrier Systems,F. H. D. Roerdink and A. M. Kroon, eds., New York: John Wiley & Sons, Ltd., pp. 131-153, (1989).
Durand-Keklikian, L. and Partch, R.E., “Microencapsulation of Oil Droplets by Aerosol Techniques—I. Metal Oxide Coatings,”J. Aerosol. Sci.19(4):511-521, Pergamon Press (1988).
Ellison, J. McK., “Adaptation of the Spinning Top Generator to Provide Aerosols in the Respirable Range,”Ann. Occup. Hyg.10:363-367, Oxford University Press (1967).
Feinstein, S.B. et al., “Microbubble Dynamics Visualized in the Intact Capillary Circulation,”J. Am. Col. Cardiol.4(3):595-600, Elsevier Biomedical (1984).
Galyean, R.D. and Cotterill, O.J., “Chromatography and Electrophoresis of Native and Spray-Dried Egg White,”J. Food Sci.44:1345-1349, Institute of Food Technologists (1979).
Grinstaff, M.W. and Suslick, K.S., “Air-filled proteinaceous microbubbles: Synthesis of an echo-contrast agent,”Proc. Natl. Acad. Sci. USA88:7708-7710, National Academy of Sciences (Sep. 1991).
Gupta, P.K. and Hung, C.T., “Al
Johnson Richard Alan
Sutton Andrew Derek
Hartley Michael
Quadrant Drug Delivery Limited
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