Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1995-06-05
1999-09-28
Manuel, George
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600431, A61B 800
Patent
active
059578483
ABSTRACT:
Microspheres are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microsphere have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilization and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 .mu.m, targeted to selected areas of the body or of prolonged life in the circulation.
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Johnson Richard Alan
Sutton Andrew Derek
Andaris Limited
Manuel George
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