Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-01
1994-08-16
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D30752
Patent
active
053388712
ABSTRACT:
Pure Form 1 ranitidine hydrochloride is prepared by a process of crystallization from a solution of ranitidine hydrochloride in a mixed solvent comprising 1 part by volume of at least one lower alkanol such as ethanol and 1-2.0 parts by volume of a C.sub.6 -C.sub.10 aromatic hydrocarbon such as toluene, and in the presence of seed crystals of pure Form 1 ranitidine hydrochloride. In the preferred process according to the invention, the ranitidine hydrochloride is prepared in situ in the solvent mixture by adding hydrochloric acid to a solution of the free base in the solvent mixture, in the presence of the seed crystals.
REFERENCES:
patent: 4460506 (1984-07-01), Bradshaw
patent: 4551548 (1985-11-01), Kleemann et al.
patent: 4613688 (1986-09-01), Inoue et al.
patent: 5075301 (1991-12-01), Sasho et al.
Antczak Casimir
McGolrick Jeffry D.
Ngooi Teng-Ko
Tindall James L. A.
Ivy C. Warren
Owens A. A.
Torcan Chemical Ltd.
LandOfFree
Preparation of form 1 ranitidine hydrochloride does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation of form 1 ranitidine hydrochloride, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of form 1 ranitidine hydrochloride will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-953249