Preparation of form 1 ranitidine hydrochloride

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D30752

Patent

active

053388712

ABSTRACT:
Pure Form 1 ranitidine hydrochloride is prepared by a process of crystallization from a solution of ranitidine hydrochloride in a mixed solvent comprising 1 part by volume of at least one lower alkanol such as ethanol and 1-2.0 parts by volume of a C.sub.6 -C.sub.10 aromatic hydrocarbon such as toluene, and in the presence of seed crystals of pure Form 1 ranitidine hydrochloride. In the preferred process according to the invention, the ranitidine hydrochloride is prepared in situ in the solvent mixture by adding hydrochloric acid to a solution of the free base in the solvent mixture, in the presence of the seed crystals.

REFERENCES:
patent: 4460506 (1984-07-01), Bradshaw
patent: 4551548 (1985-11-01), Kleemann et al.
patent: 4613688 (1986-09-01), Inoue et al.
patent: 5075301 (1991-12-01), Sasho et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Preparation of form 1 ranitidine hydrochloride does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of form 1 ranitidine hydrochloride, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of form 1 ranitidine hydrochloride will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-953249

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.