Preparation of form 1 ranitidine hydrochloride

Details Preparation of form 1 ranitidine hydrochloride Preparation of form 1 ranitidine hydrochloride

1993-04-01

1994-08-16

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30752

Patent

active

053388712

ABSTRACT:
Pure Form 1 ranitidine hydrochloride is prepared by a process of crystallization from a solution of ranitidine hydrochloride in a mixed solvent comprising 1 part by volume of at least one lower alkanol such as ethanol and 1-2.0 parts by volume of a C.sub.6 -C.sub.10 aromatic hydrocarbon such as toluene, and in the presence of seed crystals of pure Form 1 ranitidine hydrochloride. In the preferred process according to the invention, the ranitidine hydrochloride is prepared in situ in the solvent mixture by adding hydrochloric acid to a solution of the free base in the solvent mixture, in the presence of the seed crystals.

REFERENCES:
patent: 4460506 (1984-07-01), Bradshaw
patent: 4551548 (1985-11-01), Kleemann et al.
patent: 4613688 (1986-09-01), Inoue et al.
patent: 5075301 (1991-12-01), Sasho et al.

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