Preparation of fluorine derivatives of phosphonic acid

Details Preparation of fluorine derivatives of phosphonic acid Preparation of fluorine derivatives of phosphonic acid

1986-11-20

1988-07-12

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558303, 560231, C07F 940

Patent

active

047571276

ABSTRACT:
A process for the preparation of phosphonic acid compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of aryl of 6 to 14 carbon atoms, optionally unsaturated alkyl of 1 to 8 carbon atoms, aryloxy of 6 to 14 carbon atoms, optionally unsaturated alkoxy of 1 to 8 carbon atoms and aralkoxy and aralkyl of 7 to 18 carbon atoms, or R.sub.1 and R.sub.2 together with a phosphorus atom form a ring, Y is selected from the group consisting of ##STR2## and --COOR.sub.3, R.sub.3 is selected from the group consisting of optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally substituted, and ##STR3## R.sub.4 and R.sub.5 are individually selected from the group consisting of hydrogen, optionally unsaturated alkyl of 1 to 8 carbon atoms and aryl of 6 to 14 carbon atoms and R.sub.6 is selected from the group consisting of optionally unsaturated alkyl of 1 to 10 carbon atoms, optionally unsaturated cycloalkyl of 3 to 10 carbon atoms and aryl of 6 to 14 carbon atoms comprising reacting a compound of the formula ##STR4## wherein R.sub.1, R.sub.2 and Y have the above definitions and Z is selected from the group consisting of --CHO and ##STR5## and Alk is optionally unsaturated alkyl of 1 to 8 carbon atoms with fluorine to obtain the corresponding compound of formula I.

REFERENCES:
Umemoto et al., "Tetrahedron Letters," vol. 27, No. 28, (1986) pp. 3271-3274.
Reactions Chemiques Dangereuses, (1974) pp. 421-427.
Blackburn et al., "Chem. Abs.," vol. 103, (1985) 71409w.
Fokin et al., "Chem. Abs.," vol. 74, (1971) 124736s.
Grell et al., "Chem. Abs.," vol. 65, (1966) 7210h.
Grieco et al., "J. Med. Chem.", vol. 23, (1983) pp. 1077-1083.

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