Preparation of fluconazole and pharmaceutically acceptable salts

Details Preparation of fluconazole and pharmaceutically acceptable salts Preparation of fluconazole and pharmaceutically acceptable salts

1996-07-09

1998-01-20

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24908

Patent

active

057102805

ABSTRACT:
A process for preparing fluconazole, including the steps of (1) acylating 1,3-difluorobenzene (DFB) to obtain 2-chloro-2',4'-difluoroacetophenone (CAP); (2) alkylating 4-amino-4H-1,2,4-triazole (4-AT) with CAP to obtain 2-(1H-1,2,4-triazol-1-yl)-2',4'-difluoroacetophenone (TAAP) salt; (3) deaminating TAAP salt to obtain TAAP; and (4) reacting TAAP with 1,2,4-triazole to obtain fluconazole.

REFERENCES:
patent: 4404216 (1983-09-01), Richardson

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