Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-06
2000-03-28
Carlson, Karen Cochrane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514381, C07K 1400
Patent
active
060432152
ABSTRACT:
A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX.sub.a, and/or degraded factor IX peptides.
The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.
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Enkoji Takashi
Feldman Fred
Ho Laura
Huang Chin C.
Kleszynski Richard R.
Aventis Behring L.L.C.
Carlson Karen Cochrane
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