Preparation of enamines in aqueous media

Details Preparation of enamines in aqueous media Preparation of enamines in aqueous media

1992-07-30

1993-09-21

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 79, 546 93, 558414, 558418, 560 21, 560 46, 560 47, 560 48, 562435, 562453, 562456, 562457, C07C20922, C07D21910

Patent

active

052470911

ABSTRACT:
The synthesis of enamines in aqueous media and a process for the preparation of memory enhancing 9-amino-1,2,3,4-tetrahydracridines are described.

REFERENCES:
patent: 4631286 (1986-12-01), Shutske et al.
L. W. Haynes and A. G. Cook in "Enamines--Synthesis, Structure, and Reactions,", 2nd Edition, A. G. Cook, Editor, Marcel Dekker, Inc., New York, N.Y., published 1988, pp. 103 to 114, and Chapter 9.
S. F. Dyke, "The Chemistry of Enamines", Cambridge University Press, London, England, published 1973, pp. 8 and 9.
W. K. Summers, et al., The New England Journal of Medicine, vol. 315, pp. 1241-1245, published Nov. 13, 1986, entitled "Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type".
A. Osbirk and E. B. Pedersen, Acta Chemica Scandinavica B, vol. 33, published 1979, pp. 313-318, entitled "Phosphoramides, X.* Phosphorous Pentaoxide Amine Mixtures and HMPT as Reagents in the Synthesis of 4-Amino- and 4-Dimethylamino-2,3-polymethylenequinolines".
Acridines, edited by R. M. Acheson, Second Edition, John Wiley & Sons, Inc., published 1973, p. 476.
W. P. Brian and B. L. Souther, Journal of Medicinal Chemistry, vol. 8, pp. 143 to 144, published Jan., 1965, entitled "New Derivatives of 9-Amino-1,2,3,4-tetrahydroacridine".
G. K. Patnaik, et al., Journal of Medicinal Chemistry, vol. 9, pp. 483 to 488, published Jul., 1966, entitled "Compounds Acting on the Central Nervous System, IV. 1-Substituted 2,3-Polymethylenequinolines".
E. T. Michalson, et al., Heterocycles, vol. 30, pp. 415-425, published 1990, entitled "Synthesis of 9-(1-Azetidinyl)-1,2,3,4-tetrahydroacridine".
U. Edlund, Acta. Chemica Scandinavica, vol. 26, p. 2972, published 1972, entitled "2-(N-Pyrrolidyl)indene; an Enamine of Unusual Stability".
P. K. Khandelwal and B. C. Joshi, Defense Science Journal, vol. 21, pp. 199 and 200, published 1971, entitled "Preparation of 2-(N-Morpholinyl)indene and Its Unusual Stability".
P. W. Hickmott, Tetrahedron, vol. 38, pp. 2005 to 2007, published 1962, entitled "Enamines: Recent Advances in Synthetic, Spectroscopic, Mechanistic, and Stereochemical Aspects-I".

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