Preparation of dipeptides

Details Preparation of dipeptides Preparation of dipeptides

1986-04-15

1990-06-19

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435832, C12P 2102, C12P 2100

Patent

active

049353551

ABSTRACT:
A process for forming a dipeptide which is substantially free of solid dipeptide-amino acid adduct by reacting the amino acid reactants in the presence of a polyol.

REFERENCES:
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patent: 4165311 (1979-08-01), Isowa et al.
patent: 4256836 (1981-03-01), Isowa et al.
patent: 4284721 (1981-08-01), Oyama et al.
patent: 4339534 (1982-07-01), Johansen et al.
patent: 4375430 (1983-03-01), Sklavounos
patent: 4399163 (1983-08-01), Brennan et al.
patent: 4436925 (1984-03-01), Isowa et al.
patent: 4465626 (1984-08-01), Sklavounos
Homandberg et al, "Synthesis of Peptide Bonds by Proteinases. Addition of Organic Cosolvents Shifts Peptide Bond Equilibria Toward Synthesis" Biochemistry, vol. 17, No. 24, 5220-5227, 1978.
Isowa et al, "The Enzynmatic Synthesis of Protected Valine-5 Angiotensin II Amide-I", Bull. of Chem. Soc. Japan, vol. 50(10), 2766.gtoreq.2772, (1979).
Oyama et al., "A New Horizon for Enzyme Technology", Chemtech, Feb. 1984.
Isowa et al., "The Thermolysin-Catalyzed Condensation Reactions of N-Substituted Aspartic and Clutamic Acids with Phenylalanine Alkyl Esters", Tetrahedron Letters No. 28, pp. 2611-2612, 1979.
Nakanishi et al., "Continuous Synthesis of N-(benzyloxycarbonyl)-L-aspartyl-L-Phenylalanine Methyl Ester with Immobilized Thermolysin in an Organic Solvent", Bio/Technology, vol. 3, May 1985, pp. 459-464.

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