Preparation of diazabicyclic Intermediates

Details Preparation of diazabicyclic Intermediates Preparation of diazabicyclic Intermediates

1992-07-02

1993-03-23

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548452, 548532, 548542, C07D20902

Patent

active

051965488

ABSTRACT:
Diazabicyclo[2.2.1]heptane intermediates are prepared from 4-hydroxy-L-proline in a five step procedure, or from allo-4-hydroxy-D-proline, through a novel 2-(C.sub.1 -C.sub.6)alkyl-5-substituted-2,5-diazabicyclo[2.2.1]heptane intermediate. The diazabicycloheptanes are of use in the preparation of antibiotic quinolones.

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patent: 3947445 (1976-09-01), Henry
patent: 5036153 (1991-07-01), Braish et al.
The Journal of Organic Chemistry, vol. 31, 1966 P. S. Portoghese et al., pp. 1059-1062.
Baker et al J. OCS, 46, (1981), pp. 2954-2960.

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