Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1995-08-22
2000-02-08
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
106122, 106646, 2523635, 264 43, 264 46, 516928, 600443, 600453, 600458, A61K 4900, A61B 800, A61B 802
Patent
active
060225254
ABSTRACT:
Microcapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcapsules.
Suitable wall-forming materials include proteins such as albumin and gelatin.
The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.
REFERENCES:
patent: 2797201 (1957-06-01), Veatch et al.
patent: 2805977 (1957-09-01), Robinson et al.
patent: 3043782 (1962-07-01), Jensen
patent: 3501419 (1970-03-01), Bridgeford
patent: 3565559 (1971-02-01), Sato et al.
patent: 3781230 (1973-12-01), Vassiliades et al.
patent: 3863004 (1975-01-01), Wolfnagel
patent: 3960583 (1976-06-01), Netting et al.
patent: 4089800 (1978-05-01), Temple
patent: 4102806 (1978-07-01), Kondo et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4127622 (1978-11-01), Watanabe et al.
patent: 4173488 (1979-11-01), Vassiliades et al.
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4316391 (1982-02-01), Tickner
patent: 4420442 (1983-12-01), Sands
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4774958 (1988-10-01), Feinstein
patent: 4844882 (1989-07-01), Widder et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4960351 (1990-10-01), Kendall, Jr. et al.
patent: 4968562 (1990-11-01), Delgado
patent: 4981625 (1991-01-01), Rhim et al.
patent: 5069936 (1991-12-01), Yen
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5190982 (1993-03-01), Erbel et al.
patent: 5196183 (1993-03-01), Yudelson et al.
patent: 5205287 (1993-04-01), Erbel et al.
patent: 5215680 (1993-06-01), D'Arrigo
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5501863 (1996-03-01), Rossling et al.
patent: 5518709 (1996-05-01), Sutton et al.
patent: 5543162 (1996-08-01), Timonen et al.
patent: 5547656 (1996-08-01), Unger
patent: 5567414 (1996-10-01), Schneider et al.
patent: 5643553 (1997-07-01), Schneider et al.
patent: 5674468 (1997-10-01), Klaveness et al.
Aldrich, J.E. and Johnston, J.R., "Use of the Spinning Disk Technique to Produce Monodisperse Microspheres of Human Serum Albumin for Labelling with Radioisotopes," Int. J. Appl. Radiat. Isotopes 25:15-18 (1974).
Barnhart, J., et al., "Characteristics of Albunex: Air-Filled Albumin Microspheres for Echocardiography Contrast Enhancement," Invest. Radiol. 25:s162-s164 (1990).
Basu, S. and Bhattacharya, G., "Some Aspects of the Phenomenon of Coacervation," Science 115:544-545 (1952).
Conte, U., et al., "Spray Dried Albumin Microspheres Containing Nicardipine," Eur. J. Pharm. Biopharm. 40(4):203-208 (Aug. 1994).
Ellison, J. McK., "Adaptation of the Spinning Top Generator to Provide Aerosols in the Respirable Range," Ann. Occup. Hyg. 10 :363-367 (1967).
Feinstein, S.B. et al., "Microbubble Dynamics Visualized in the Intact Capillary Circulation," J. Am. Coll. Cardiol. 4(3 ):595-600 (1984).
Galyean, R.D. and Cotterill, O.J., "Chromatography and Electrophoresis of Native and Spray-Dried Egg White," J. Food Sci. 44:1345-1349 (1979).
Grinstaff, M.W. and Suslick, K.S., "Air-filled proteinaceous microbubbles: Synthesis of an echo-contrast agent," Proc. Natl. Acad. Sci. USA 88: 7708-7710 (1991).
Gupta, P.K. and Hung, C.T., "Albumin microspheres I: physico-chemical characteristics," J. Microencapsulation 6(4):427-462 (1989).
Haghpanah, M., et al., abstract presented at British Pharmaceutical Conference, King's College, London (1991).
Heller, J., "Controlled release of biologically active compounds from bioerodible polymers," Biomaterials 1:51-57 (1980).
Kawashima, Y. et al., "Preparation of multiple unit hollow microspheres (microballoons) with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behavior (in vitro)," J. Contr. Rel. 16(3):279-290 (1991).
Kondo, A., Microcapsule Processing and Technology, Van Valkenburg, J.W. (Ed.), New York: Marcel Dekker, Inc. pp. 18-20, 61, 68, 70, 90-92, 106-109, 118-119 (1980).
Modler, H.W. and Emmons, D.B., "Calcium as an Adjuvant for Spray-Drying Acid Whey," J. Dairy Sci. 61(3):294-299 (1978).
Ophir, J. et al., "Aqueous Solutions as Potential Ultrasonic Contrast Agents," Ultrasonic Imaging 1(3):265-279 (1979).
Ophir, J. et al., "Ultrasonic Backscatter from Contrast Producing Collagen Microspheres," Ultrasonic Imaging 2 :67-77 (1980).
Parkinson, T.L., "Effects of Spray-Drying and Freezing on the Proteins of Liquid Whole Egg," J. Sci. Fd Agric. 26:1625-1637 (1975).
Raju, A. et al., "Human Serum Albumin Microspheres for Lung Imaging--Preparation and Evaluation," Isotopenpraxis 14(2):57-61 (1978).
Sato, T. et al., "Porous Biodegradable Microspheres for Controlled Drug Delivery. I. Assessment of Processing Conditions and Solvent Removal Techniques," Pharm. Res. 5(1):21-30 (1988).
Scheffel, U. et al., "Albumin Microspheres for Study of the Reticuloendothelial System," J. Nucl. Med. 13(7):498-503 (1972).
Schlief, R., "Ultrasound contrast agents," Curr. Opin. Radiol. 3:198-207 (1991).
Schneider, M. et al., "Polymeric Microballoons as Ultrasound Contrast Agents--Physical and Ultrasonic Properties Compared with Sonicated Albumin," Investig. Radiol. 27(2):134-139 (Feb. 1992).
Shapiro, J.R. et al., "Intravenous Contrast Echocardiography With Use of Sonicated Albumin in Humans: Systolic Disappearance of Left Ventricular Contrast After Transpulmonary Transmission," J. Am. Coll. Cardiol. 16(7):1603-1607 (1990).
Takenaka, H. et al., "Mechanical Properties, Dissolution Behavior and Stability to Oxidation of L-Ascorbylmonostearate Microcapsules prepared by a Spray-Drying Polycondensation Technique," Chem. Pharm. Bull. 30(6):2189-2195 (1982).
Wheatley, M.A. et al., "Contrast agents for diagnostic ultrasound: development and evaluation of polymer-coated microbubbles," Biomaterials 11:713-717 (1990).
Widder, K.J. et al., "Magnetically Responsive Microspheres and Other Carriers for the Biophysical Targeting of Antitumor Agents," Adv. Pharmacol. Chemother. 16:213-271 (1979).
Baveja, S. K. et al., "Microencapsulation of soluble pharmaceuticals," J. Microencasulation 3(1):33-37 (1986).
Beller, G. A. et al., "Assessment of Regional Myocardial Perfusion by Positron Emission Tomography after Intracoronary Administration of Gallium-68 Labeled Albumin Microspheres," J. Computer Assisted Tomography 3(4):447-452 (1979).
Cheng, K. T. et al., "The Production and Evaluation of Contrast-Carrying Liposomes Made with an Automatic High-Pressure System,"0 Investigative Radiol. 22(1):47-55 (1987).
Clausen, G. et al., "Distribution of blood flow in the dog kidney. III. Local uptake of 10 .mu.m and 15 .mu.m microspheres during renal vasodilation and constriction," Acta Physiol. Scand. 113:471-479 (1981).
Cremers, H. F. M. et al., "Albumin-Heparin Microspheres As Carriers for Cytostatic Agents," J. Controlled Release 11:167-179 (Jan. 1990).
Davis, S. S. and L. Illum, "Microspheres As Drug Carriers," in: Drug Carrier Systems, F. H. D. Roerdink and A. M. Kroon, eds., New York: John Wiley & Sons, Ltd. pp. 131-153 (1989).
Durand-Keklikian, L. and R. E. Partch, "Microencapsulation of Oil Droplets by Aerosol Techniques--I. Metal Oxide Coatings," J. Aerosol Sci. 19(4):511-521 (1988).
Kwok, K. K. et al., "Production of 5-15 .mu.m Diameter Alginate-Polylysine Microcapsules by an Air-Atomization Technique," Pharm. Res. 8(3):341-344 (Mar. 1991).
Levy, M.-C. and M.-C. Andry, "Mixed--walled microcapsules made of cross-linked proteins and polysaccharides: preparation and properties," J. Microencapsulation 8(3):335-347 (Sep. 1991).
McArdle, C. S. et al., "Cytotoxic loaded albumin microspheres: a novel approach to regional chemotherapy," Br. J. Surg. 75:132-134 (1988).
Pande, S. et al., "Preparation, chacterization and performance evaluation of neomycin-HSA microspheres," J. Microencapsulation 7(2)
Heath David
Johnson Richard A.
Senior Peter J.
Sutton Andrew D.
Lovering Richard D.
Quadrant Healthcare (UK) Limited
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