Preparation of coupled hemoglobin molecules

Details Preparation of coupled hemoglobin molecules Preparation of coupled hemoglobin molecules

1975-10-20

1982-06-22

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, 2601125R, 424177, A61K 3514, C07G 700, C07C10352, A61K 3700

Patent

active

043362486

ABSTRACT:
Hemoglobin molecules are coupled so as to increase their intravascular residence times without significantly diminishing their oxygen transport ability. This is achieved by coupling hemoglobin molecules to one another and/or to serum proteins and gelatin derivatives using dialdehydes such as aliphatic dialdehydes of 3 to 8 carbon atoms, optionally followed by addition of pyridoxal phosphate. The desired material isolated by ammonium sulfate precipitation, the sulfate being added before, simultaneously with, or after the dialdehyde. Solution of the precipitate followed by dialysis and/or ion exchange can also be undertaken.

REFERENCES:
patent: 3925344 (1975-12-01), Mazur
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4009267 (1977-02-01), Huber et al.
Rabiner et al., J. Expl. Med., vol. 126, (1967), pp. 1127-1142.
Ciba-Geigy, Documents, Scientific Tables, (1973), p. 597.
Savitsky et al., Clin. Pharmacol. Ther., Jan. 1978, pp. 73-80.
Wold, Methods in Enzymology, XI, 617-618, 638-639 (1967).
Fasold et al., Angew. Chem. Internat. Ed., 10, 795-801 (1971).

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