Preparation of colloidal aqueous solutions of active substances

Details Preparation of colloidal aqueous solutions of active substances Preparation of colloidal aqueous solutions of active substances

1997-07-30

1998-12-15

Kishore, Gollamudi S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554213, 424450, C07C 5300, C07C 5700

Patent

active

058499415

ABSTRACT:
A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula ##STR1## wherein m, a, b, x and y have the meanings indicated in the description.

REFERENCES:
patent: 3288824 (1966-11-01), Mahler
patent: 4654370 (1987-03-01), Marriott
patent: 5434282 (1995-07-01), Stern

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